In my case, getting paid $110k/year in a country that pays $40k/year as the cap (and the currency is 2:1). I'm at it for six months and I have a huge family around me -- helps with the isolation. I will jump on a plane friday and work 3 weeks from the beach, and once I feel this remote thing has stabilized I will move to the countryside to about half the cost of living, so in one year going from the local national market cap to almost 6 times that, working much less (more focus without the office interruptions and away from the 8 hours sitting=8 hours of work) will be attractive to some people like it is to me, I guess.
That is what appeals to me...the freedom to work from anywhere in the world, especially places with a lower cost of living. But even if I stayed local, it would be nice to just be free from a daily commute and regular hours. Most of the time I'm very productive at 5am-7am and 10pm-2am. My 3 month old daughter is most active between 9am and 5pm, so it would be nice to spend this part of the day with her. I'm still looking for a company that is open to remote work.
I've been doing remote work since college, and I travel all the time while working. That may be the best part of remote work. I even worked for a few weeks on a cruise ship. As long as there's an Internet connection, I can do my job.
As for the isolation thing, my family is usually at home, and I also go out a lot during the day.
I can imagine, if I were simply home alone for most of the day, that it'd get lonely and being able to go to the "office" to be around people would seem like a good trade.