It's not "easy" but it remains true. We can play the moral-decision game and I'll ask you whether killing one child is justified to save 5,000,000. If you answer "yes" then from that point it's just about agreeing on numbers.
What is the alternative you propose? Just to give a hypothetical-but-realistic example, let’s presume that khamenei’s continued existence results in 100 civilian deaths per day. Under that assumption, what one-time cost would you accept to end his life?
Whether or not one would accept deaths of civilians to get rid of Khamenei, I don't think anyone should accept a school full of children being blown up for no obvious reason. If there was somehow a reason why Khameni could not have killed without attacking that school, then those reasons should be plainly spelled out and evidence presented. As things stand with the limited information we have now, it just looks like a war crime with no strategic upside.