I have played through Deus Ex HR (and MD) on Bazzite albeit on an AMD GPU. You should generally be able to do it with Proton (GE recommended) either Steam (recommended) or Heroic (if you bought them from GOG).
Witcher 1/2 at least also worked OOB via steam.
For some context/ user comments, see Deus Ex HR[0] and System Shock 2[1] on protondb.
Witcher 1/2 at least also worked OOB via steam.
For some context/ user comments, see Deus Ex HR[0] and System Shock 2[1] on protondb.
[0]: https://www.protondb.com/app/238010 (gold, deck status: playable) [1]: https://www.protondb.com/app/238210 (platinum, deck status: playable)