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Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news.

My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU.

The long-term systemic effects of these drugs are still largely unknown.



> The long-term systemic effects of these drugs are still largely unknown.

The long term effects of obesity are very well known though and unlikely to be better than any still unknown negative effect semaglutide might have.


Haven’t these types of drugs been in use for ~15 years?


> Haven’t these types of drugs been in use for ~15 years?

The predecessor of semaglutide, liraglutide has been sold since 1998. GLP-1 has been studied since the 70s. The first human was injected with GLP-1 agonists in 1993 IIRC.


Further, Ozempic itself is nearly 10 now and some people have been on Exenatide for 20+ years continuously now.

These drugs are not novel, or new and we absolutely know the long term health impact.


20 years isn't a lot of time


If the side effects are mild enough I don't notice for 20+ years, that's fine by me. I'll take it. Obesity had side effects that were killing me.


You don't think her being 87 might have something to do with her complications?


Well also short term complications don't imply long term complications.

If you're allergic to peanuts it doesn't mean everyone is going to suffer some huge medical crisis from peanuts in 20 years.


It is a well Mongolian effect of Ozempic.

She stopped using the drug and the problems disappeared.


Maybe don’t give them to grandma? Idk man but at 87 anything that happens might as well have been the grim reaper deciding it was their time.




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