Pi holes don't swallow everything, in stream ads like on Youtube and Twitch and served by the domain all make it through the Pi hole approach. It also doesn't allow you to turn it off for a particular page or site either, if you want to allow ads on Phronix you can't do it without enabling that advertiser everywhere since it lacks the context of the DNS calls.

The advantage is it works with every browser on every device, its network wide and it blocks a tonne of other calls that aren't made by the browser such as telemetry.