A thread going into what Knuth meant by that quote that is usually shortened to "premature optimization is the root of all evil". Or, to rephrase it: don't tire yourself out climbing for the high fruit, but do not ignore the low-hanging fruit. But really I don't even see why "scripting languages" are the particular "high level" languages of choice. Compilers nowadays are good. No one is asking you to drop down to C or C++.