The much bigger problem is that you not only have to deal with the technical challenges, but also the visual design challenges where non-technical people have all kinds of opinions that you have to deal with. Things get really nasty once you have to implement features that emulate non-web functionality like right-click menus and the UI becomes an inconsistent mess.
Visual Design Challenges is one I hear most frontend developer complain about. I explained a queen duck (https://bwiggs.com/notebook/queens-duck/) to one of them and he started doing that several times in his project. If you look at this git repo, there would be commits called "queen duck" right before he would demo so he could get feedback about the "mistake" he made, revert the commit and move on with his life.
