There are times when it is indeed different. When Columbus landed, it was genuinely different. (Especially for the natives.) When general artificial intelligence arrives, it will also be genuinely different. (Especially for us.)
I'm not sure if you just implicitly suggested that we (humans) will be mistreated by the general AI (and its offsprings) just like the natives were mistreated by people who followed after Columbus.
Or on the flip side, we might treat the AI's worse due to being so scared of them, as in the situation in Neuromancer where all the AI's legally have to be built with a kill switch.
There are times when it is indeed different. When Columbus landed, it was genuinely different. (Especially for the natives.) When general artificial intelligence arrives, it will also be genuinely different. (Especially for us.)