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> And all the studies (that I'm aware of, at least) using psychedelics and therapy to treat mental health conditions don't use doses high enough for the kind of trips they can create those experiences - the goal is to have a strong enough effect that the brain and its thought patterns are more malleable than usual, but not so strong that the patient focussed on the trip rather than on the talking therapy.

I think you’re misinformed on this. Most modern psychedelic research is not focused on actively participating in therapy during the psychedelic experience itself. Typical doses used in trials are actually very large — verging on a “heroic dose” in some cases. E.g. see: https://bigthink.com/series/the-big-think-interview/psychede...

“My therapeutic research with psychedelics is primarily used 'psilocybin,' which is the agent in magic mushrooms. The dose we now give to patients is anywhere from 30 milligrams to 40 milligrams, which Terence McKenna, who's the famous psychedelic bard would refer to repeatedly as the "heroic dose."



Thanks for the new info, I hadn't heard of the study you linked.

I'm sceptical of your claim that "MOST (emphasis mine) modern psychedelic research is not focused on actively participating in therapy during the psychedelic experience"

I don't have time to look into what the split between the two approaches is now days, but it's an interesting enough question that I'll definitely find some time to get my knowledge caught up in the near future. Almost certainly not fast enough for this HN thread to still be alive by the time I have, but I'll reply to you if/when I'm able to either agree that you were right or explain why wrong, in case you're interested and in case you notice when someone replies to an older comment or yours (which can be achieved with the handy HN Replies, built by a longtime HN reader, which I personally think is a great tool filling a gap that HN should have had as a default feature - https://www.hnreplies.com/ )


A quick scan of the literature appears to confirm this trend, also showing the increased effectiveness of a large dose, however there certainly are studies using a lower dose as you described.

E.g. https://www.sciencedirect.com/science/article/pii/S0924977X2...




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