The Fairphone is going to be sold in the US in partnership with the e.Foundation which develops /e/OS (another deGoogled android fork), and is what's going to come preinstalled on the Fairphone https://murena.com/america/shop/smartphones/brand-new/murena...
I have been a happy user of an /e/OS Fairphone 3+ for two years. I just use it like my Samsung before, nothing special to do (other than choosing non Google apps, obviously).