Serious? I pre & post all of those + bicycling. Whammy, huge difference, especially if you leverage e.g. the caffeine for mental work, or whatever else each chemical is good at.

Had some funny experiments in there but would never go back to nothing. It doesn't make sense, especially if you don't have an addictive personality & any chemical risk is more likely associated with quitting beneficial chemicals than staying on them too long.