NextDNS + Ublock Origin (or Brave Browser, since it uses the UBO lists by default) is a really good combo on its own, and easy enough for my self-proclaimed "tech illiterate" friends to set up and use.

Also, it's pretty cool that NextDNS has this: https://github.com/nextdns/nextdns/wiki

I think I found NextDNS here on HN and I've been really happy with it.

gorhill isn't updating uMatrix anymore. That said, I still use it in addition to uBO because I find it very intuitive to use.