If you mean graphics tablets like the Wacom displays with the pens, no. It works fine with parametric graphics or CAD, for example, so long as I stick to simple dimensions so one hand is on the numpad while the other holds the pen but the second I need full words - like variable names in complex equations, renaming groups or layers, fuzzy searching for a brush or color by name, etc. - putting the pen back down (without losing it!) becomes too cumbersome. It either serves to interrupt the creative process or get in my way when I know what I want and just want to do it as quickly as possible.

It gets worse since touch screens are actually pretty imprecise so I end up using a 3D mouse for viewport manipulation and a regular mouse for precise navigation (nested menus!) on top of the pen and keyboard. At least one of the input devices is considered lost at any given time.