I have been taking Rapamycin for 19 weeks and NR and Metformin (for anti-aging) for much longer and I can't see any difference. I'm 50+. I generally, however, feel excellent, as well as I remember when I was younger so long as I have gotten lots of sleep and don't have a cold. When I'm sick or tired I feel much worse than I did, however.

Finding a doctor who's up to "non-traditional" support can be a challenge, but you've inspired me to start that search.

Besides satisfying their altruism they have nothing to gain and everything to lose if this miracle drug causes cancer in 5 years.

I read up ok it. It can literally cause cancer.

Depending on where you are, everything can cause cancer.

This website is known to the State of California to cause cancer.

One of the additives I work with in pottery is labeled with a prop 65 warning. The only ingredient is silicon dioxide, aka sand.

Which can lead to silicosis, which itself then leads to lung cancer.

This is also used as an anti-caking agent in food. Does CA label foods in that manner? Seems like it would cause confusion for the average consumer.

Which one, NMN or Rapa?

This doctor will prescribe it, he does telemed / remote calls, works out of Texas: https://www.theprivatepractices.com/services/rapamycin

What's NMN?

Nicotinamide Mononucleotide, an unregulated supplement.

Note also:

> We found that, when data from all organisms studied were combined for each compound, aspirin resulted in the highest percent increase in average lifespan (52.01%), followed by minocycline (27.30%), N-acetyl cysteine (17.93%), nordihydroguaiaretic acid (17.65%) and rapamycin (15.66%), in average.[0]

Though I'd consider whether flies and worms are good models for your human self.

0: https://pubmed.ncbi.nlm.nih.gov/34687363/

> Though I'd consider whether flies and worms are good models for your human self.

Even other vertebrates don't share the human cancer model, so people are absolutely jumping the gun assuming that this generalises to us.

But I'd imagine (and hope) that it's mostly laymen (and quacks in the supplement business) that are pushing the notion that the evidence is in?

Is NMD related to NAD+?

Yes, it is a precursor to NAD

See also B3 (niacin aka nocotinic acid) in the Krebs cycle.

Thanks!

Yeah as others appointed out it’s a nad+ precursor.

I feel compelled to comment though because anytime I read about how this stuff is only been tested in worms in mice… That automatically discount it’s worth as something to consider.

I’m gonna sah what I said before - I’ve played high-level hockey my whole life, I’m now 55 and I play against guys that barely washed out of their pro career.

When I stop taking nmn for two months my speed dropped from 20+ Mph to the mid teens.

A week after resuming my NMN supplementation my speeds are back in the 23-24 mph range

There’s just no way to fake it against players of this caliber. And to be clear I don’t know anybody even close to my age competing at this level.