CLOG and the full UI builder CLOG Builder do exactly what you are looking for.

It already offers plugin controls that work with the builder or just code.

Can deliver native local apps, websites, webapps, iOS and Android apps, etc.

Database controls like in VB and Delphi - and much more to come.

It is programmed in and with Common Lisp, however you can easily program events in JavaScript and Python coming soon too.

https://github.com/rabbibotton/clog