That is an argument they are making to explain the putative infection of wild-type mice, yes. Maybe it is true, but it doesn't invalidate any of the things I wrote.

The headline you used doesn't mention that this is a paper in mice, so you failed to accurately summarize one of the most important parts. So important, in fact, that it's in the title of the paper.

Edit: the link you are citing does not say what you're suggesting. "Neuroepithelium" means "epithelial cells surrounding the neurons". The paper is suggesting that they found signs of ACE2 expression in this epithelial tissue.

I’m sorry, I don’t understand. You didn’t bring up NRP1 At all in your argument when clearly this is what the paper about.

SAR2 is entering the neuron via NRP1 and ACE2.

They infect mice that express ACE2 on their neurons, and see obvious signs of infection.

They also infect wild-type mice, and see greatly reduced response in the same experiment, but claim that this is still non-zero. They hypothesize that NRP1 is mediating the infection.

The evidence for this claim is not definitive. It's an intriguing hypothesis. It's still not a paper about humans.

The fact that NRP1 assists SARS2 infection has been known for over a year. I still don’t get your point.

This is important because it can explain the neurological symptoms of Covid and possible pathway for treatment of those neurological symptoms. To anyone, like me, who had psychosis at the beginning of their Covid infection, or people who are suffering from long Covid, this is very important.

There have been papers showing that NRP1 interacts with furin-cleaved spike protein. There have been some suggestions that this assists in entry for non-neural cells. There have never been papers (to my knowledge) that show that this plays a role in neuronal infection in humans. Like ACE2, NRP1 is associated with endothelial cells.

Again, this is a research paper, in mice. It has no direct relevance to any symptom you have personally experienced.

> This study is just showing the infection in the neuron can/may/does precede it’s appearance in the serum.

That's pretty interesting, what does this mean for anything. Like does it change how tests should work? vaccines? any mitigation measure?

It will probably mean a lot regarding cognitive function and psychosis to those are risk genetically. Changes in NRP1 are linked to mood disorders like schizophrenia and depression.

I think it also shows that this is the pre-symptomatic time of the infection.

My own experiences with Covid was I had a psychotic break two days before I had a fever. I have a history of psychosis.

It’s also important to note that the Epstein-Barr virus also uses NRP1.

In my humble opinion, I feel that the destruction of NRP1 and ACE2 are responsible for many of the comorbidities we find after infection with SARS2.