Ive been using these two in combination for a little while and found it to be a significant improvement to my web experience. I also use the ekill[0] extension to remove annoying flashing elements or banners that wont go away.
I use the I Don't Care About Cookies and Cookie AutoDelete add-ons too.
I also use Behind The Overlay Revival[0] for annoying overlays. I just have to click the toolbar button - not even aim at the elements I want to remove.
That said, ekill's grudge mode looks interesting.
And I use Unstick![1][2] which can get rid of annoying fixed headers and footers that chew into your vertical space.
[0] https://addons.mozilla.org/en-US/firefox/addon/ekill/