Is it even possible we ever end with conclusive research that could be applied at large scale ? I think you won't have much choice than try and see if it works for you specifically.
We could have more lab mice studies, but it wouldn't account for actual humans' different metabolism, include lifestyle (work, daily rhythm, mental state), actual food intake, genetics etc.
Looking at other human related health subject, for instance we haven't hit any conclusive point on any specific food that is widespread today. Everything regarding fat, proteins, sugar etc. is still small scale, extremely biased, often politicized and producing contradictory results. All we know for sure is that "too much" is not good, and that's after decades and decades of research.
I think it's hard but absolutely posssible, but the quality of statistics in nutrition research depresses me. Good work exists, but the publication incentives do not lead it to rise to the top, meaning the correlation between study quality and study size isn't good. AFAIK, and I am not up-to-date, there are no large studies that (i) are constructed to gather data on enough variables and (ii) do the data gathering well-enough that the data won't be too noisy.
We could have more lab mice studies, but it wouldn't account for actual humans' different metabolism, include lifestyle (work, daily rhythm, mental state), actual food intake, genetics etc.
Looking at other human related health subject, for instance we haven't hit any conclusive point on any specific food that is widespread today. Everything regarding fat, proteins, sugar etc. is still small scale, extremely biased, often politicized and producing contradictory results. All we know for sure is that "too much" is not good, and that's after decades and decades of research.