Sublingual tablets are available which result in a much more reliably fast absor... | Hacker News

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		xvedejas on Sept 6, 2021 \| parent \| context \| favorite \| on: Melatonin: Much More Than You Wanted to Know (2018... Sublingual tablets are available which result in a much more reliably fast absorption. I recommend them for anyone who wants less variability from their melatonin use.

polskibus on Sept 6, 2021 [–]

Any links on why are sublingual better wrt absorption?

nextaccountic on Sept 6, 2021 | | [–]

It bypasses the stomach and intestines. It also bypasses liver metabolism (first-pass metabolism)

https://en.wikipedia.org/wiki/Sublingual_administration#Prin...

https://en.wikipedia.org/wiki/First_pass_effect

relaxing on Sept 6, 2021 | | [–]

Short answer is because the chemical goes directly through the membrane into the bloodstream.

https://en.m.wikipedia.org/wiki/Sublingual_administration

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