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Afaik at least for the Adenovirus based ones these have not been used before as well.


There are several adenovirus based vaccines, including vaccines for tuberculosis and influenza, among others. The first adenovirus vaccine I'm aware of was developed in the 1970s.

https://en.wikipedia.org/wiki/Viral_vector


According to [1] there are only Covid and Ebola approved vaccines based on an Adenovirus vector. Only for the latter we have a couple of years of data and I am not sure whether it has been administered to large populations.

For tuberculosis there is no approved vector based vaccine [2]. Neither for influenza [3].

[1] https://en.wikipedia.org/wiki/Viral_vector_vaccine

[2] https://en.wikipedia.org/wiki/Tuberculosis_vaccines

[3] https://en.wikipedia.org/wiki/Influenza_vaccine#Manufacturin...




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