Every major web framework's standard build tools (Create-React-App, Vue-CLI, etc), are based on Webpack + Babel, and most folks who are using one of those frameworks but setting up their own build toolchains still base them around Webpack + Babel.
There's some potentially interesting technical alternatives out there, but Babel is a keystone in the modern JS ecosystem.
Every major web framework's standard build tools (Create-React-App, Vue-CLI, etc), are based on Webpack + Babel, and most folks who are using one of those frameworks but setting up their own build toolchains still base them around Webpack + Babel.
There's some potentially interesting technical alternatives out there, but Babel is a keystone in the modern JS ecosystem.