I see these issues all the time, with enterprise desktop apps. The scaling is only really a problem because it is enabled by default when you plug in certain displays. If the user made a conscious choice (which they would easily remember if they had trouble), it would be fine.
For many, many years there were at the very most 120 dpi monitors, with almost all being 96, and I imagine a lot of enterprise applications have those two values (maybe 72 as well) hard-coded and don't behave properly with anything else.
