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I don't know if it was a top answer when you looked 8 hours ago, but a cardiovascular physiologist answered (14 hours ago) a very thorough, detailed answer with second-order explanations. It's now _the_ top comment, here is a direct link with tracking removed:

https://www.reddit.com/r/askscience/comments/fm2z8x/if_a_hea...



I was thinking of that answer too. It talks about the ways heart muscle is different from skeletal muscle, which is cool, but I don't see it carry those differences through into explaining about fatigue...


It mostly just mentions mitochondria and lactate though. I think it’s still subject to the same criticism.




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