Muscle cells don't replicate past early childhood development, they just get bigger and add more nuclei. So muscle cancers are extremely rare compared to cancers of other tissues.
each nucleus contains a full genomic content.
muscles are more of a "myosynsynctium" than a group of cells.
there are cohorts of cells that are more prone to becoming cancer due to thier developmental origins and the complement of developmental mechanisms that can be reactivated.
things such as cell adhesion, and cell migration through tissue dermal cells are good at this as they do these things over the course of development.
muscles are built where they will live so these features are inhibited somewhat more completely and harder to "switch on or off"
Neat, but why don't all the cells in our body do that? What's the trade-off that goes the other way for cells most likely to get cancer (prostate, breast, lungs, lymph nodes)?
