Greater Appalachia definitely extends through PA in a T shape across the center of the state and the northern border (sometimes called Pennsyltucky) and covers at least the Southern Tier in New York.
Like most states, Pennsylvania's rural areas tend to be more conservative and support Republicans. The resulting political map of Pennsylvania is therefore a red "T" in the center of the state with the Pittsburgh and Philadelphia areas a strong blue.
Putting Upstate into one bucket is going to be problematic no matter what label you give it. The southern tier is definitely Appalachia, the eastern side is Yankeedom, and WNY is heartland.
Where the people live (I assume you mean front range area) is a mix of Far West and Left Coast -- the newcomers are more the latter, and they seem to influence the previous population. You'll know that is is no longer Far West when TABOR is repealed.
Also, many of the Midwest states are less Yankeedom and more Heartland.
Also, Dallas is Greater Appalachia and not Deep South yet Houston is Deep South and not New France?
Also, LA is El Norte and not the Left Coast?
Was this map based on 200 year old data?