The House is the chamber with actual power, while the Senate was intended to act as a check on the House and the executive. That's why the 17th amendment made such a mess: they were supposed to represent state interests, and especially having a balanced budget is much more a state interest than a popular interest.
In particular, for any bill requiring spending, the Senate can only amend a bill that started in the House. Impeachment must start in the house and is then tried in the Senate. The Senate can't nominate someone to office, they can only confirm a nominee presented by the executive.
This isn't a spatial metaphor any more than "upperclassmen" and "underclassmen" are for high schools or "left" and "right" are for politics. We call it the "upper" chamber because it's supposed to be the higher status, more "dignified" chamber.
Words have histories of course, and probably at one point this was a spatial metaphor - maybe some bicameral legislature literally did have one of their higher status body on a different floor than their lower status body. But the words upper and lower when applied to the legislative branch have evolved since then.