Clamav (clamWin) will happily false positive and quarantine all sorts of files on a windows box, occasionally including required system files. I've tried it on 3 different boxes at different times over the past ~5 years and the amount of false positives was insane every time.

I don't think its ready to be run on Windows boxes unless you are a power user willing to manually verify ~100 files are not actually malware.